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KMID : 1161420210240080883
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Journal of Medicinal Food
2021 Volume.24 No. 8 p.883 ~ p.893
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Effects of ID-HWS1000 on the Perception of Bowel Activity and Microbiome in Subjects with Functional Constipation: A Randomized, Double-Blind Placebo-Controlled Study
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Kim Min-Cheol
Lee Sung-Hee
Park Jin-Kyung
Park Jong-Mi
Lee Dong-Hun
Park Jae-Wan
Kim Byung-Yong
Cho Min-Seok
Kim Tae-Yoon
Park Ha-Young
Park Ju-Hyun
Bok Min-Kyung
Lim Hyun-Jung
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Abstract
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During constipation, indigestible foods, such as probiotics, prebiotics, and dietary fiber, may improve the bowel environment and activity. In this randomized, double-blind, and placebo-controlled study, the effects of ID-HWS1000, composed of Lactobacillus and Bifidobacterium species, xylooligosaccharide, and dietary fiber, were evaluated to determine whether it improves the perception of bowel activity or cause changes in the gut microbiome. Thirty Korean adults with “functional constipation” according to the Rome III criteria were randomly assigned to the following groups: 20 in the ID-HWS1000 group and 10 in the placebo group. ID-HWS1000 or the placebo was consumed by the participants for 4 weeks. To assess the changes in the perception of bowel activity, clinical data and gut microbiome analyses were conducted before and after the experiment. There were significant differences between the groups in the response to 9 of the 12 survey questions (the number and duration of bowel movements, amount of feces, number of irritant bowel movements, number of times bowel movements felt incomplete, shape of the feces, amount of gas in the gut, discomfort after defecation, and discomfort owing to constipation) (P?
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KEYWORD
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bowel movements, functional constipation, gut microbiome, prebiotics, probiotics
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